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KMID : 0371919890020010025
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Journal of Wonju College of Medicine
1989 Volume.2 No. 1 p.25 ~ p.32
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In Vitro Susceptibility of Cryptococcus neoformans to Amphotericin B, 5-Fluorocytosine, Ketoconazole, Miconazole and Rifampicin Alone and in Combination
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Abstract
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In vitro activities of experimental antifungal agents were studied to determine the minimum inhibitory concentrations and possible drug interaction in combination of amphotericin B/ketocoazole, amphotericin B/miconazole, ketoconazole/miconazole, ketoconazole/rifampicin and miconazole/rifampicin.
The minimum inhibitory concentrations of 5 experimental antifungal agents for these strains were ranged as amphotericin B; 0.39 mcg/㎖-1.56mcg/㎖, 5-fluorocytosine; 0.25mcg/㎖-6.25mcg/㎖, ketoconazole; 0.047mcg/㎖-0.0094mcg/㎖, miconazole; 0.78mcg/㎖-1.56mcg/㎖ and rifampicin; >100.0mcg/㎖. in all of the strains, ketoconazole had a greatest antifungal activity on the dilutioin basis.
When a checkerboard technique was used amphotericin B acted synergistically with ketoconazole and miconazole whereas rifampicin had no synergistic effect.
In the cases of ketoconazole (0.023mcg/㎖) and miconazol (0.39 mcg/㎖) can be found only indifferent activity.
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